Nonanticoagulant heparin inhibits NF-kB activation and attenuates myocardial reperfusion injury
نویسندگان
چکیده
VINOD H. THOURANI, SUKHDEV S. BRAR, THOMAS P. KENNEDY, LISA R. THORNTON, JOHN A. WATTS, RUSSELL S. RONSON, ZHI-QING ZHAO, ANNE L. STURROCK, JOHN R. HOIDAL, AND JAKOB VINTEN-JOHANSEN Departments of Internal Medicine and Emergency Medicine and the Cannon Research Center, Carolinas Medical Center, Charlotte, North Carolina 28232; Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine and Carlyle Fraser Heart Center Cardiothoracic Research Laboratory, Crawford Long Hospital, Atlanta, Georgia 30365; and Division of Respiratory, Critical Care and Occupational (Pulmonary) Medicine, University of Utah, Salt Lake City, Utah 84132
منابع مشابه
Nonanticoagulant heparin inhibits NF-kappaB activation and attenuates myocardial reperfusion injury.
Heparin reduces ischemia-reperfusion injury to myocardium. This effect has been attributed to complement inhibition, but heparin also has other activities that might diminish ischemia-reperfusion. To further probe these mechanisms, we compared heparin or an o-desulfated nonanticoagulant heparin with greatly reduced anticomplement activity. When given at the time of coronary artery reperfusion i...
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Background: Unit of p65 is one of the subunits of NF-κB and its phosphorylation by stress oxidative causes activation of NF-κB. The aim of present study was to investigate the effects of adenosine injection after brain ischemia reperfusion injury on gene expression of NF-κB /p65 and Reactive Oxygen Species (ROS) in hippocampus tissue of male wistar rats. Methods: 40 male wistar rats were rando...
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تاریخ انتشار 2000